Of the other ties, League new boys, Accrington Stanley have been handed a dream start to their return to the Football League with a home tie against Nottingham Forest.
Ironic that having cancelled a pre-season friendly against the Franchise holders, in preference for a trip to Dean Court that Colchester United have to travel to the National Hockey Stadium!
Here's the full Southern draw:
Cardiff City v Barnet
Franchise FC v Colchester United
Swindon Town v Brentford
Crystal Palace v Notts County
Hereford Unite v Coventry City
Swansea City v Wycombe Wanderers
Peterborough United v Ipswich Town
AFC Bournemouth v Southend United
Brighton & Hove Albion v Boston United
Cheltenham Town v Bristol City
Millwall v Gillingham
Southampton v Yeovil Town
Birmingham City v Shrewsbury Town
Plymouth Argyle v Walsall
Bristol Rovers v Luton Town
QPR v Northampton Town
Torquay United v Norwich City
Leyton Orient v West Bromwich Albion
Franchise FC v Colchester United
Swindon Town v Brentford
Crystal Palace v Notts County
Hereford Unite v Coventry City
Swansea City v Wycombe Wanderers
Peterborough United v Ipswich Town
AFC Bournemouth v Southend United
Brighton & Hove Albion v Boston United
Cheltenham Town v Bristol City
Millwall v Gillingham
Southampton v Yeovil Town
Birmingham City v Shrewsbury Town
Plymouth Argyle v Walsall
Bristol Rovers v Luton Town
QPR v Northampton Town
Torquay United v Norwich City
Leyton Orient v West Bromwich Albion
Visit the Football League site for the full draw.