French defender Distin will officially leave Dean Court when his contract expires next month, along with Stephane Zubar, Josh Carmichael, Josh Wakefield, Mason Walsh and Jon Muleba.
Distin joined Bournemouth last summer as manager Howe eyed experience to underpin the club's first top-flight foray.
Howe believes 38-year-old Distin's guidance and calming influence proved pivotal to Bournemouth securing a second season in the Premier League.
"Sylvain was a vital part of our squad throughout the season," Howe told the Bournemouth Echo.
"Going into the Premier League, we felt bringing someone with vast experience and knowledge of the division would be hugely beneficial to our squad and give them someone to lean on."
Former Everton, Manchester City and Portsmouth defender Distin boasts more than 450 Premier League appearances.
The evergreen centre back set a new Premier League appearance record for a foreign player in his Bournemouth spell, with manager Howe consistently impressed by his professionalism and dedication.
"Sylvain played that role perfectly, but he also played his part on the pitch and was involved in some pivotal games
It was a really good experience for the other players to have worked with him for a year and I would like to thank him for his efforts."