Big spending Shrewsbury Town (5th) were humbled by Conference North side Blyth Spartans 3-1 away from home. A Reay brace in the 1st and 29th minutes got the non-Leaguers off to a great start, with Todd adding to the tally in the 53rd minute. Holt pulled one back in the 68th minute, but it was no where near enough.
Darlington (1st) live to tell the take as they were held 0-0 by Droylsden of the Conference.
Luton Town (24th) were held to a 0-0 by Conference side Altrincham at Kenilworth Road.
Lincoln City (11th) were held to a 1-1 draw by Conference North leaders Kettering at Rockingham Road. Geohaghan gave Kettering the lead in the 85th minute, but this was cancelled out immediately when N'Guessan levelled a minute later.
There were three League Two sides who managed to cause an upset by beating League One opposition. Bradford City (3rd) managed to beat Franchise FC away from home, winning 2-1. Daley gave City a 2nd minute lead, which was cancelled out by Johnson in the 43rd minute. City booked their place in the second round with an 82nd strike from Lee.
Port Vale (13th) booked their place in round two, at the expense of Huddersfield Town at the Galpharm Stadium in a 7-goal thriller. Dodds gave Vale a 27th minute lead, which was cancelled out by Collins on the stroke of half time. Craney (51st min) and Williams (65th min) gave Town a 3-1 lead, but probably didn't reckon on Howland (79th min), Dodds (85th min) and Richards (92nd min) hitting back to claim a place in the next round.
AFC Bournemouth (23rd) saw off Bristol Rovers for the 2nd time this season in a cup competition at Dean Court. Pearce scored the only goal of the game in the 75th minute, which saw both sides reduced to 10-men in separate incidents.
Accrington Stanley (16th) held Tranmere Rovers at Livingstone Road to a 0-0 draw.
Dagenham & Redbridge (8th) held Hereford United to a 0-0 draw at Edgar Street.
Barnet (18th) and Rochdale (6th) will have to replay following a 1-1 draw at Underhill. Dagnall gave the visitors a 49th minute lead, but saw Yakubu level in the 67th minute.
Bury (7th) were undone by a single goal at home against Gillingham (10th). Barcham booked the Gills place in round two with a 71st minute strike.
Chesterfield (12th) booked their place in the next round with a 3-1 win over Conference side Mansfield Town at Saltergate. A Winter brace (32nd & 58th min), with a Ward strike (51st min) was more than enough for the Conference outfit, who could only respond through Arnold in the 78th minute.
Aldershot Town (14th) and Rotherham United (21st) will have to replay following a 1-1 draw at The Recreation Ground. Cummins must have thought that he'd done enough with a 54th minute strike. But Town struck back with a 93rd min penalty through Grant.
Notts County (14th) scraped past Ryman League side Sutton United. Butcher scored the only goal of the game in the 75th minute.
Morcambe (17th) compounded the misery for Grimsby Town (22nd), with a 2-1 win at Christie Park. A Taylor brace just before the break and in the 77th minute only draw a response from Stockdale in the 88th minute - which came too late to force a replay.
No surprise at the Deva Stadium as Chester City (19th) slipped to a 3-0 home defeat at the hand of Millwall. Grabban (76th min), Harris (79th min) and Grimes (93rd min) was enough for London side to book their place in the second round.
Macclesfield (20th) saw off Harlow of the Ryman Premier with a 2-0 away win. Brisley gave the Silkmen a 65th minute lead, which was added to by Dinfield in the 86th minute to book a place in the next round.
Brentford (9th) visit last seasons giant killers Havant & Waterlooville (Conference South) in a Sunday game, and Wycombe Wanderers (2nd) visit Conference South side AFC Wimbledon on Monday evening.